![]() are specified from among the ventral epidermal Pn.p cells. their fates in a precise spatial pattern: 3 ° -3 ° - 2 ° -1 ° - 2 ° -3 ° ( Figure 3 ). The vulval lineages are of two types, 1 ° and 2 °, each of which generate distinct sets of progeny. VPCs specifies three VPCs to generate vulval cells ( Figure 2 ). ![]() LET-23 and RAS LET-60 (see RTKRas/MAP kinase signaling ), LIN-12 (see LIN-12/Notch signaling in C. Both EGF and LIN-12 prevent precursor cells from adopting the 3 ° fate. EGF promotes the 1 ° fate while LIN-12 promotes the 2 ° fate. Nuclear targets of the LET-23-LET-60-MPK-1 pathway 4. Non-graded action of LIN-3: sequential induction 4.5. The anchor cell is necessary and sufficient 4. Multiple redundancies program precision 9. Coupling of LET-23 and LIN-12 signaling 8.1. Overview of VPC 1 ° - 2 ° -3 ° pattern formation 3.1. Hox gene lin-39, competence, and fusion 2.3. Generation of vulval precursor cells 2.1. types of vulval development mutants 1.3. Download all chapters : WormBook.zip (380 MB)
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